The Krebs Cycle Enzyme α-Ketoglutarate Decarboxylase Is an Essential Glycosomal Protein in Bloodstream African Trypanosomes
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منابع مشابه
The krebs cycle enzyme α-ketoglutarate decarboxylase is an essential glycosomal protein in bloodstream African trypanosomes.
α-Ketoglutarate decarboxylase (α-KDE1) is a Krebs cycle enzyme found in the mitochondrion of the procyclic form (PF) of Trypanosoma brucei. The bloodstream form (BF) of T. brucei lacks a functional Krebs cycle and relies exclusively on glycolysis for ATP production. Despite the lack of a functional Krebs cycle, α-KDE1 was expressed in BF T. brucei and RNA interference knockdown of α-KDE1 mRNA r...
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1 The Krebs Cycle Enzyme -Ketoglutarate Decarboxylase is an Essential 2 Glycosomal Protein in Bloodstream African Trypanosomes 3 4 5 Steven Sykes *1,2 , Anthony Szempruch *1 and Stephen Hajduk 1 6 7 1 Department of Biochemistry and Molecular Biology; University of Georgia; 8 Athens, GA 30602 9 10 11 12 13 14 15 16 *Steven Sykes and Anthony Szempruch contributed equally to these studies. 17 18 ...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2015
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.00214-14